Background: Clinical studies of the associations of vitamin E with lung function have reported conflicting results.\r\nHowever, these reports primarily examine the a-tocopherol isoform of vitamin E and have not included the isoform\r\n?-tocopherol which we recently demonstrated in vitro opposes the function of a-tocopherol. We previously\r\ndemonstrated, in vitro and in animal studies, that the vitamin E isoform a-tocopherol protects, but the isoform\r\n?-tocopherol promotes lung inflammation and airway hyperresponsiveness.\r\nMethods: To translate these findings to humans, we conducted analysis of 4526 adults in the Coronary Artery\r\nRisk Development in Young Adults (CARDIA) multi-center cohort with available spirometry and tocopherol data in\r\nblacks and whites. Spirometry was obtained at years 0, 5, 10, and 20 and serum tocopherol was from years 0, 7\r\nand 15 of CARDIA.\r\nResults: In cross-sectional regression analysis at year 0, higher ?-tocopherol associated with lower FEV1 (p = 0.03\r\nin blacks and p = 0.01 in all participants) and FVC (p = 0.01 in blacks, p = 0.05 in whites, and p = 0.005 in all\r\nparticipants), whereas higher a-tocopherol associated with higher FVC (p = 0.04 in blacks and whites and p = 0.01\r\nin all participants). In the lowest quartile of a-tocopherol, higher ?-tocopherol associated with a lower FEV1\r\n(p = 0.05 in blacks and p = 0.02 in all participants). In contrast, in the lowest quartile of ?-tocopherol, higher\r\na-tocopherol associated with a higher FEV1 (p = 0.03) in blacks. Serum ?-tocopherol >10 Ã?µM was associated\r\nwith a 175ââ?¬â??545 ml lower FEV1 and FVC at ages 21ââ?¬â??55 years.\r\nConclusion: Increasing serum concentrations of ?-tocopherol were associated with lower FEV1 or FVC, whereas\r\nincreasing serum concentrations of a-tocopherol was associated with higher FEV1 or FVC. Based on the prevalence of\r\nserum ?-tocopherol >10 Ã?µM in adults in CARDIA and the adult U.S. population in the 2011 census, we expect that the\r\nlower FEV1 and FVC at these concentrations of serum ?-tocopherol occur in up to 4.5 million adults in the population.
Loading....